Thorne Methyl-Guard Plus

Thorne Methyl-Guard Plus gives your body the full methylation support it needs to sustain energy production, protect cardiovascular health, and recover efficiently from hard training. Four active B vitamins — already converted into the forms your body can immediately use — work alongside 1.8g of betaine to keep your methylation cycle running at full capacity, even under high training loads.

Athletes with high training volume, plant-based or low-meat diets, known MTHFR variants, or anyone whose bloodwork has flagged low B12 can benefit from Thorne Methyl-Guard Plus. And if you have the MTHFR variant, most B supplements deliver far less than their label suggests. Methyl-Guard Plus delivers active forms that skip the conversion step entirely.

Immediate Absorption, No Conversion Needed – Methyl-Guard Plus delivers methylcobalamin B12, 5-MTHF folate, pyridoxal 5'-phosphate B6, and riboflavin 5'-phosphate B2 — all in active, tissue-ready forms. Your body uses them immediately, without the conversion step that standard B vitamins require and that many athletes' genetics can't complete efficiently.

Dual-Pathway Methylation Support – Each full serving provides 1.8g of betaine (trimethylglycine), a direct methyl donor that gives your body a second independent route to maintain healthy homocysteine levels and keep methylation-dependent processes — energy metabolism, neurotransmitter production, DNA repair — running under pressure.

Sustained Energy and Sharper Recovery – When your methylation cycle is running efficiently, your body produces energy more consistently, repairs muscle tissue faster, and clears metabolic waste between sessions. Athletes on Methyl-Guard Plus report a noticeable lift in energy baseline and recovery quality within two to four weeks of daily use.

How to Use Thorne Methyl-Guard Plus

Daily Dose: Take 1–3 capsules daily with a meal. For full methylation support, three capsules is one serving — spread across the day if you're starting out to build tolerance.

Timing: Take with food. Morning with breakfast is the most consistent approach and avoids the mild stimulating effect some athletes notice from high-dose methylcobalamin close to bedtime.

Pro Tip: New to active-form B vitamins? Start with one capsule and build up over a week. Sensitive individuals can feel the difference with high-dose methylcobalamin, so ease in.